University of Basrah
  • Register
  • Login
  • العربیة

The Medical Journal of Basrah University

Notice

As part of Open Journals’ initiatives, we create website for scholarly open access journals. If you are responsible for this journal and would like to know more about how to use the editorial system, please visit our website at https://ejournalplus.com or
send us an email to info@ejournalplus.com

We will contact you soon

  1. Home
  2. Volume 32, Issue 1
  3. Author

Current Issue

By Issue

By Subject

Keyword Index

Author Index

Indexing Databases XML

About Journal

Aims and Scope

Editorial Board

Advisory Board

Editorial Staff

Facts and Figures

Publication Ethics

Indexing and Abstracting

Related Links

Peer Review Process

News

HLA-DQA1 and HLA-DQB1 genotyping among lichen planus patients in Basrah‏ ‏province ‎

    Nibras S. Al-Ammar

The Medical Journal of Basrah University, 2014, Volume 32, Issue 1, Pages 43-53
10.33762/mjbu.2014.94512

  • Show Article
  • Download
  • Cite
  • Statistics
  • Share

Abstract

Background: Lichen planus is an inflammatory, pruritic disease of the skin and mucus membranes, which can be ‎either generalized or localized. Many studies indicated that human leukocyte antigens might have a role in lichen ‎planus (LP). As far as my knowledge, no previous study had done in Iraq about HLA-DQA1 and -DQB1 alleles ‎frequencies in patients with lichen planus. ‎
Aim: The aim of the present study is to investigate the additional genetic contribution to lichen planus susceptibility ‎lying on the HLA region, by focusing on the possible differential contribution of the different DQA1 and DQB1 carrying ‎haplotypes.‎
Method: The present study was carried out in College of Medicine during the period between (2012-2014). 50 patients ‎with lichen planus attending Basrah General Hospital and private clinic, and 50 healthy controls‏ ‏were included in the ‎study, with age group from (13-67) years. 100 DNA samples were purified from the blood samples of patients and ‎controls, and then followed by PCR amplification of HLA-DQA1 and DQB1 genes in Cell Research Unit, Biology ‎Department, College of Science, University of Basrah. The sequencing-PCR was done in Korea, Bioneer sequencing ‎laboratories. ‎
Results & Conclusions: Results indicated statistically significant decreased frequencies of HLA-DQA1*010201 ‎‎(P<0.005), DQA1*0201 (P < 0.05), and -DQB1*030201 (P < 0.005) alleles in lichen planus patients, which indicated ‎that these alleles might be a protective factors. Results also indicated statistically significant increased frequencies of ‎DQA1*010401 (P<0.005), DQA1*040101 (P<0.005) DQA1*050101 (P<0.005), DQB1*030101 (P<0.005) and ‎DQB1*050101 (P<0.005) alleles in lichen planus patients, which indicated that these alleles might be risk factors and ‎increase the ability of infection. The present study indicates that genetic constitution through HLA-DQ locus determines ‎the mechanism of disease as well as clinical and pathologic outcomes. More studies are necessary to test genetic ‎dependencies on the basis of larger samples which would increase statistical power. An accurate definition of disease ‎susceptible alleles will improve our understanding of antigen presentation mechanisms prevailing in the etiology of the ‎disease. This knowledge is necessary for the design of improved immune intervention strategies to halt lichen planus ‎progression in patients at risk of developing the disease or those who are already suffering from it.‎
Keywords:
    HLA DQA DQB Lichen planus
  • PDF
  • XML
(2014). HLA-DQA1 and HLA-DQB1 genotyping among lichen planus patients in Basrah‏ ‏province ‎. The Medical Journal of Basrah University, 32(1), 43-53. doi: 10.33762/mjbu.2014.94512
Nibras S. Al-Ammar. "HLA-DQA1 and HLA-DQB1 genotyping among lichen planus patients in Basrah‏ ‏province ‎". The Medical Journal of Basrah University, 32, 1, 2014, 43-53. doi: 10.33762/mjbu.2014.94512
(2014). 'HLA-DQA1 and HLA-DQB1 genotyping among lichen planus patients in Basrah‏ ‏province ‎', The Medical Journal of Basrah University, 32(1), pp. 43-53. doi: 10.33762/mjbu.2014.94512
HLA-DQA1 and HLA-DQB1 genotyping among lichen planus patients in Basrah‏ ‏province ‎. The Medical Journal of Basrah University, 2014; 32(1): 43-53. doi: 10.33762/mjbu.2014.94512
  • RIS
  • EndNote
  • BibTeX
  • APA
  • MLA
  • Harvard
  • Vancouver
  • Article View: 231
  • PDF Download: 143
  • LinkedIn
  • Twitter
  • Facebook
  • Google
  • Telegram
  • Home
  • Glossary
  • News
  • Aims and Scope
  • Privacy Policy
  • Sitemap

 

 
This journal is licensed under a Creative Commons Attribution 4.0 International (CC-BY 4.0)

Powered by eJournalPlus