EVALUATION OF LIPID AND LIPOPROTEIN PROFILE IN PATIENTS WITH TYPE 2 DIABETES
The Medical Journal of Basrah University,
2010, Volume 28, Issue 1, Pages 27-32
Objective: To evaluate the pattern of lipid and lipoprotein profile in patients with type 2 diabetes (T2D).
Methods: In this prospective study, which was carried out in Basrah, Southern Iraq, serum concentrations of glucose
“fasting blood sugar” (FBS), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low density
lipoprotein-cholesterol (LDL-C), triglycerides (TG) and very low density lipoprotein-cholesterol (VLDL-C) were
measured in 92 patients (43 males and 49 females) with T2D and 120 control subjects (35 males and 85 females).
Results: Patients with T2D have significantly higher serum concentrations of TC, LDL-C, TG, VLDL-C and LDLC/
HDL-C ratio (P<0.001) and significantly lower HDL-C serum concentration (P<0.001) compared to control
subjects. Male patients with T2D showed significantly higher TC, LDL-C serum concentrations and LDL-C/HDL-C
ratio in comparison to control subjects (P<0.001), while serum HDL-C concentration was significantly lower among
T2D patients compared to controls (P<0.001). No significant differences were seen in serum TG and VLDL-C
concentrations between male patients and control subjects (P>0.05). In females, serum levels of TC, LDL-C, TG,
VLDL-C, and LDL-C/ HDL-C ratio were significantly higher (P<0.001), and serum HDL-C level was significantly
lower (P<0.05) in patients with T2D than in control subjects.
Conclusion: T2D has marked effects on lipid and lipoprotein profile causing a diversity of dyslipidaemia, that
might lead to atherosclerosis, and hence, increasing the risk of coronary heart disease.
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