The Medical Journal of Basrah University

Abstract

ABSTRACT
Vitex (known locally as kaf murium) has along history of traditional use in women. The effect of alcoholic extract of
vitex agnus-castus was examined for its effect on some blood parameters in mice (Mus Musculus). Mice in the
treatment groups were injected intraperitoneally with two doses (6 mg and 12 mg / mouse) of vitex extract while the
control group received distilled water daily for two weeks. Blood parameters (RBC, Hb, PCV) showed a significant
decrease with both doses in comparison to the control group (P<0.01), while no significant decrease in (WBC) was
found. Biochemical parameters (total serum protein, total serum cholesterol) showed a significant decrease in the
treatment groups as compared with the control group (P<0.01). In conclusion, vitex agnus-castus alcoholic extract
can have a significant adverse effect on blood. Its cholesterol lowering effect worths investigation in the future.