Host-Trichomonas vaginalis relationship was investigated by establishing an infected laboratory mouse model by a local
strain. BALB/c mice were inoculated S/C (5 mice) and I/P (5 mice) with a medium containing Trichomonas vaginalis. At
the same time, another mice were inoculated S/C (5 mice) and I/P (5 mice) with a medium only to serve as a control
groups. There were ascites and multiple abscesses on the visceral organs during post-mortem of mice injected
intraperitoneally (I/P). There was a localized abscess at the site of subcutaneous (S/C) injection of T. vaginalis. The
histopathological changes of the internal organs and skin were studied and reported for the infected and control mice
.Conclusion: There were pathological changes in mice infected with T.vaginalis local strain. Such animal model is useful
for pathological, biochemical and therapeutic investigations.