Abstract
Background: Diabetes mellitus type 2, which has recently become a global health issue, is a multi-etiological metabolic disease characterized by persistent hyperglycemia due to defects of insulin secretion and its action, associated with abnormality in carbohydrates, lipid and metabolism proteins. Dyslipidemia is a common feature of T2DM. Endoglin is a transforming Growth Factor β co-receptor, homodimer, transmembrane glycoprotein linked by disulfide bond. This study aimed to investigate the relation between sENG levels and dyslipidemia among type 2 diabetic patients, also to evaluate their relationship with diabetic complication.
Methods: Eighty-nine patients with T2DM are enrolled, with 89 apparently healthy persons with the same age and sex as controls. Sociodemographic characters and anthropometric measurements were informed for both cases and controls. Overnight fasting samples were collected for biochemical analysis (soluble ENG, FBG, HbA1c and lipid profile).
Results: The type 2 diabetic patients sENG level was significantly higher than controls. Also, increase sENG levels in diabetic patients have FBG levels more than (130 mg/dl), HbA1c greater than 7% and in diabetic complication cases was statistically significant than controls. The type2 diabetic lipid profile was higher than in control with statistically significant difference.
Conclusions: An increase of sENG level in diabetic patients and in patients with diabetic complications especially in those with more than one complication, indicate that sENG may be used in the development and prognosis of DM and resulted complications.
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