Abstract
Background: glutathione peroxidase, catalase, and superoxide dismutase enzymes are the main antioxidants that serve as the body's
first line of defence against oxidative stress.
The aim of the study: To examine 5-selenocyanatouracil anti-inflammatory and antioxidant properties.
Materials and methods: Four groups of rats were employed; the control group received distilled water the paracetamol group
received 500 mg/kg body weight of paracetamol, the paracetamol & 5-Selenocyanatouracil groups received 50 mg/kg of 5-
selenocyanatouracil after 30 minutes of paracetamol, and the second paracetamol & 5-Selenocyanatouracil group received 100 mg/kg
of 5-selenocyanatouracil after 30 minutes of paracetamol administration.
Results: The findings demonstrated that 5-selenocyanatouracil considerably (p<0.05) raised levels of superoxide dismutase and
glutathione reductase while notably lowering levels of Malondialdehyde and Interleukin-6.
Conclusion: The findings showed that the prepared 5-selenocyanatouracil compound had antioxidant and anti-inflammatory activity.
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