Abstract
Background: Psoriasis is a persistent, non-infectious skin condition that impacts people of all ages and has no sex preference, which
is caused by environmental stressors involving skin cells, immunocytes, and several biological signalling molecules. Recent studies
propose that the underlying mechanisms of psoriasis may involve an elevated production of (ROS) and indicate that individuals with
psoriasis exhibit elevated levels of reactive oxygen species (ROS) in their skin. Protein carbonylation is a widely adopted biomarker
for indicating protein oxidation. The objective of this study was to examine serum protein carbonylation levels as a marker of protein
oxidation in psoriasis patients, evaluating the impact of age, body mass index (BMI), and waist circumference (WC) on these levels.
Methods: Conducted as a case-control investigation, this study enlisted 98 psoriasis patients and 81 healthy individuals, matched in
terms of age and sex as controls. Blood samples, obtained through venipuncture (5 ml), were analyzed for protein carbonyl, random
blood sugar, lipid profile, liver enzymes, and complete blood count (CBC).
Results: The study found a significant difference in the mean value of serum protein carbonyl among patients with psoriasis as
compared to the control group (3.82 ± 2.24 ng/ml vs. 3.28 ± 2.54 ng/ml) respectively (P<0.05).
Conclusion: The study observed a non-significant negative correlation between levels of protein carbonyl and both age and the
duration of psoriasis. Additionally, there was no significant negative correlation found between protein carbonyl levels and waist
circumference, indicating that central obesity may render individuals more susceptible to protein oxidation, even when their BMI is
found within the normal range.
Main Subjects
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