Abstract

Objective: To clarify the relationships between Serum uric acid with inflammatory laboratory markers and ASDAS-ESR disease activity score in patients with ankylosing spondylitis.
Method: A total of 73 ankylosing spondylitis patients with age ≥ 20 years with AS fulfilling ASAS criteria were included cross-sectional study. The laboratory measures included values of uric acid, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) obtained.
Disease activity is calculated by Ankylosing Spondylitis Disease Activity Score (ASDAS- ESR). Demographic and laboratory investigations were recorded.
Results: The mean age of the studied sample was 35.04±7.99 years with a range of (17-52 years) & the mean Body Mass Index was 27.91 ±5.78 with a range (18-46).
The majority of them were married (80.8%), working (94.5%), and non-smokers in (52.1 %) and (94.5%) on biological therapy. Comparing serum uric acid with ESR value revealed no statically significant association (P=0.47). Again, this is observed when comparing serum uric acid with CRP Value (P=0.27).
Ultimately, the study failed to demonstrate any affiliation between Serum uric acid with any level of disease activity measured through ASDAS-ESR score (P =0.52).
Conclusion: The study was unsuccessful to validate any association between Serum uric acid and the routine inflammatory markers and AS disease activity score (ASDAS-ESR).