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Study of Interleukin 6 as marker of inflammation and a predictor of in-hospital complications in patients with acute coronary syndrome

    Sally Abdul-Raheem Alhumrani Nidham Mohammed Jamalludeen Abdulameer Abdulbari Abdulhameed

The Medical Journal of Basrah University, 2020, Volume 38, Issue 2, Pages 115-119
10.33762/mjbu.2020.128197.1032

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Abstract

Abstract:
Background
Although abnormal fatty deposits of infected arterial plaque play a major role in the formation of atherosclerotic plaque, activation of inflammatory cells plays a major role in the instability of the plaque and the cause of acute coronary syndrome. The aim of this study was to measure the level of interleukin-6 and to study its association with complications that occur in hospital in patients with acute coronary syndrome.
Method:
One hundred and twenty-five patients with acute coronary syndrome and 120 healthy individuals as a control group were included in this study. According to ECG and serum troponin changes, the patient group was classified into three ST-elevated myocardial infarction, ST non-elevated myocardial infarction and unstable angina. Sandwich ELISA was used by commercial groups (LEGAND MAX TM) for the IL-6 assay.
Result:
This study shows significantly significant differences in the level of IL-6 in patients with acute coronary syndrome (73.37 pg / dL) compared to the control group (9.47 pg / dL) (P value 0.001)
There were no significant differences at the level of IL-6 in patients with acute coronary syndrome and conventional risk factors (P. value <0.05).
There were significant differences in the level of IL-6 in all forms of ACS. (P. value 0.001). And those patients who had complications in hospital had a higher IL-6 level (92.89 Pg / dl) than those without complications (68.83 Pg / dl) P. value (0.012).
Conclusion:
This study indicated that IL-6 was significantly elevated in ACS patients
Keywords:
    ACS,, ,،,؛interleukin-6,, ,،,؛STEMI,, ,،,؛NSTEMI,, ,،,؛unstable angina
Main Subjects:
  • Clinical Microbiology
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(2020). Study of Interleukin 6 as marker of inflammation and a predictor of in-hospital complications in patients with acute coronary syndrome. The Medical Journal of Basrah University, 38(2), 115-119. doi: 10.33762/mjbu.2020.128197.1032
Sally Abdul-Raheem Alhumrani; Nidham Mohammed Jamalludeen; Abdulameer Abdulbari Abdulhameed. "Study of Interleukin 6 as marker of inflammation and a predictor of in-hospital complications in patients with acute coronary syndrome". The Medical Journal of Basrah University, 38, 2, 2020, 115-119. doi: 10.33762/mjbu.2020.128197.1032
(2020). 'Study of Interleukin 6 as marker of inflammation and a predictor of in-hospital complications in patients with acute coronary syndrome', The Medical Journal of Basrah University, 38(2), pp. 115-119. doi: 10.33762/mjbu.2020.128197.1032
Study of Interleukin 6 as marker of inflammation and a predictor of in-hospital complications in patients with acute coronary syndrome. The Medical Journal of Basrah University, 2020; 38(2): 115-119. doi: 10.33762/mjbu.2020.128197.1032
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