Main Subjects : Oncology


Overview of Iraqi experience in management of acute promyelocytic leukemia

Waseem Al-Tameemi; Zahra’a S. Shakir

The Medical Journal of Basrah University, 2021, Volume 39, Issue 1, Pages 21-30
DOI: 10.33762/mjbu.2021.129847.1068

Background & Objectives
In Iraq, leukemia is the 4th most common cancer, Acute promyelocytic leukemia contributes to 2.83%, and 3.18% of leukemia in Iraqi males and females respectively. This study is to review of acute promyelocytic leukemia patients presentation and management outcome in Iraq
Patients and Method
A hospital based case series study was conducted over a period of 15 months in different hematology centers. A total of 58 acute promyelocytic leukemia patients were enrolled in this study (53 newly diagnosed and 5 relapsed cases). Diagnosis based on of morphology with or without cytogenetic study.
Results
The mean age was 33.1±13.8 years, with slight female predominance. Most cases presented at winter season (39.7%). Sanz severity scoring classification as; (25.9%) low risk, (53.4%) intermediate risk, and (20.6%) high risk disease. Induction protocol consist of chemotherapy plus ATRA in (58%) while (36.2%) received only ATRA plus ATO. At the end of induction, 86.2% of patients have complete remission, while only 13.8% have failure of induction due to death. Induction mortality was higher in those who have received chemotherapy based regimens. At relapse, a second complete remission has been achieved in 4 out of 5 cases (80%).

Conclusion
There is a predilection of acute promyelocytic leukemia to young age group and winter season presentation. The choice of non-chemotherapy regimens, especially for the low and intermediate risk group, showed no drawback in complete remission rate. Disease outcome in Iraq has improved over several years due to increasing experience with using different regimen

Body Weight Changes in 210 Breast Cancer Patients after Finishing Chemotherapy; Cross Sectional Study

Hasson Mahdi Ali; Elaf MuhammedSaleh Al-Tawri

The Medical Journal of Basrah University, 2020, Volume 38, Issue 2, Pages 120-126
DOI: 10.33762/mjbu.2020.128412.1037

Abstract
Background and aim:
Increasing body weight in breast cancer patients after finishing chemotherapy is a rising health problem among many countries; this study try to evaluate this health issue among breast cancer patients attended Basra Oncology Center.
Patients and Methods:
This cross sectional study carried out on 210 patients with breast cancer who received chemotherapy at Basra oncology center, from 2017 to 2019. The participant's personal data and the other clinical information were derived from patient file.
Results:
Weight changes after finishing chemotherapy occurred in about 95% of breast cancer patients, and measurement of body mass index of patients at the start and at the end of chemotherapy revealed more women occupied the obese strata after completing the chemotherapy. The study showed statistically significant differences in the weight changes among the age, weight at diagnosis, state of hormone receptor & marital status subgroups. The only significant predictors of body weight changes after completing chemotherapy were patient age and body mass index at time of diagnosis.
Conclusion:
There is a significant weight gain in breast cancer patients in Basra Oncology Center after finishing chemotherapy.