Main Subjects : Clinical Microbiology

Thyroid function abnormalities in hepatitis C positive patients in a single center in Basrah

Amar Alaa Hussein; Alaa Mousa

The Medical Journal of Basrah University, 2022, Volume 40, Issue 1, Pages 20-29
DOI: 10.33762/mjbu.2022.132265.1092

Background: Hepatitis c virus (HCV) is global health problem it has many extrahepatic manifestations including hematologic, lymphoproliferative, endocrine, and renal diseases. The most common and important endocrine disorder are thyroid abnormalities.
The aim of this study: Is to investigate the correlation between HCV infection and thyroid function abnormalities and the factors that may affect it.
Patients and methods: This were a case-control study with 51 patients (27 males) were HCV positive who were attending Faiha Gastroenterology and Hepatology center and 49 HCV negative persons (34 males) from health workers and patients’ relatives represent control group. They were sent for thyroid function test in form of Thyroid stimulating hormone (TSH), free tetraiodothyronine (FT4), total triiodothyronine (T3), anti-thyroid peroxidase antibody, thyroglobulin, and anti-thyroglobulin.
Results: thyroid function abnormalities were found in eighteen patients (35.3%) of HCV positive group ,and nine (18.4%)in control group but the difference was not significant (p = 0.057), also there was no difference in thyroid antibodies prevalence between the two groups (p ˃ 0.05).The distribution of thyroid abnormalities in HCV patients was as follows: Four patients (7.8%) have hypothyroidism, Four (7.8%) have subclinical hypothyroidism, and Ten (19.7%) have weird thyroid function, while in control group: Four (8.2%) have subclinical hypothyroidism, Five(10.2%) have weird thyroid function and none have hyperthyroidism in both groups. Abnormal thyroid function was more in women with age group 30-40 years and was statistically significant.
Conclusion: Thyroid abnormalities are more in HCV positive patients where hypothyroidism is the most frequent, they are more in women, and more in 30-40 years old.
With the majority of hypothyroidism has autoimmune origin.

Study of Interleukin 6 as marker of inflammation and a predictor of in-hospital complications in patients with acute coronary syndrome

Sally Abdul-Raheem Alhumrani; Nidham Mohammed Jamalludeen; Abdulameer Abdulbari Abdulhameed

The Medical Journal of Basrah University, 2020, Volume 38, Issue 2, Pages 115-119
DOI: 10.33762/mjbu.2020.128197.1032

Although abnormal fatty deposits of infected arterial plaque play a major role in the formation of atherosclerotic plaque, activation of inflammatory cells plays a major role in the instability of the plaque and the cause of acute coronary syndrome. The aim of this study was to measure the level of interleukin-6 and to study its association with complications that occur in hospital in patients with acute coronary syndrome.
One hundred and twenty-five patients with acute coronary syndrome and 120 healthy individuals as a control group were included in this study. According to ECG and serum troponin changes, the patient group was classified into three ST-elevated myocardial infarction, ST non-elevated myocardial infarction and unstable angina. Sandwich ELISA was used by commercial groups (LEGAND MAX TM) for the IL-6 assay.
This study shows significantly significant differences in the level of IL-6 in patients with acute coronary syndrome (73.37 pg / dL) compared to the control group (9.47 pg / dL) (P value 0.001)
There were no significant differences at the level of IL-6 in patients with acute coronary syndrome and conventional risk factors (P. value <0.05).
There were significant differences in the level of IL-6 in all forms of ACS. (P. value 0.001). And those patients who had complications in hospital had a higher IL-6 level (92.89 Pg / dl) than those without complications (68.83 Pg / dl) P. value (0.012).
This study indicated that IL-6 was significantly elevated in ACS patients

Bacterial contamination associated with mobile phones used by students at Basrah Medical College, Basrah, Iraq

Nidham Mohammed Jamalludeen

The Medical Journal of Basrah University, 2020, Volume 38, Issue 1, Pages 58-66
DOI: 10.33762/mjbu.2020.127020.1011

Bacterial contamination associated with mobile phones used by students at Basrah Medical College, Basrah, Iraq

Background: Cell phones are increasingly becoming an important vector for pathogens, especially when they are combined with unhealthy behaviors that speed up the spread of nosocomial infections.
Objectives: This study was conducted to investigate microbial contamination of mobile phones belonging to students of Basrah Medical College, located in the southern region of Iraq.
Methods: Samples were collected aseptically with sterile swabs moistened with sterile normal saline solution over a period of four weeks. One hundred mobile devices were included in this study. The wet swab was rolled over the exposed surfaces of the mobile phones.
Results: Of 100 swabs samples, 137 isolates were identified. Of these, Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa were the most frequently identified microorganisms, in addition to other important pathogens.
Conclusion: This study showed that mobile phones are potential carriers for the spread of many pathogens, and a measure of cleanliness must be introduced to prevent the possibility of cross contamination. It was also revealed that bacteria colonized mobile phones of medical students and the contaminated mobile phones are able to transport microbes that may be able to produce serious disease.

Key words: Basrah, Medical students, Mobile phone, Staphylococcus spp.