Keywords : ,،,؛Breast cancer,,

Association between Taq1 rs: 731236 SNP of VDR gene and risk factor among Sudanese patients with breast cancer

Amira S. Khalafalla; Abuagla Dafalla; Yousif Abdelhameed Mohammed; Adam D. Abakar; Mergani Adil; GadAllah osman Modawe

The Medical Journal of Basrah University, 2021, Volume 39, Issue 2, Pages 104-110
DOI: 10.33762/mjbu.2021.130830.1082

Background: Breast cancer is the most frequent cancer in women globally as well asSudan, it has risen to become the second commonest cause of death in women.Vitamin D receptor (VDR) is a ligand-dependent transcription factor. Vitamin D-ligandedVDR, has anti-proliferative properties in a variety of tumor types by inducing cell cycle arrest, senescence, differentiation, and death. The role of VDR TaqI polymorphism is currently unknown. However, studies suggest that these polymorphisms may affect messenger RNA (mRNA) stability.
Methods and patients: This case control 198 participants, (97) breast cancer patients and another 101control group. Data was collectedby a questionnaire. 2 ml of venous blood was collected and stored at -20 till DNA extraction. Phenol chloroform method was used for DNA extraction. VDR TaqI was examined and genotyped using CTPP-PCR after designing of suitable primers and PCR condition. Then data was analyzed statistically using the SPSS program (version 21) and the SNPS tats online tool.
Results: The three genotypes reported in this study for TaqI SNP (CC, TC, and TT) were evenly distributed throughout cases and controls, so according to this findings there is no statistically significant association of this SNP with breast cancer risk (p. value 0.650) (OR(95%CI) 1.39 (0.64-3.00), 1.00 (0.54-1.87), 1.00).
Conclusions: This study found no association of TaqI polymorphism and breast cancer risk factors

Body Weight Changes in 210 Breast Cancer Patients after Finishing Chemotherapy; Cross Sectional Study

Hasson Mahdi Ali; Elaf MuhammedSaleh Al-Tawri

The Medical Journal of Basrah University, 2020, Volume 38, Issue 2, Pages 120-126
DOI: 10.33762/mjbu.2020.128412.1037

Background and aim:
Increasing body weight in breast cancer patients after finishing chemotherapy is a rising health problem among many countries; this study try to evaluate this health issue among breast cancer patients attended Basra Oncology Center.
Patients and Methods:
This cross sectional study carried out on 210 patients with breast cancer who received chemotherapy at Basra oncology center, from 2017 to 2019. The participant's personal data and the other clinical information were derived from patient file.
Weight changes after finishing chemotherapy occurred in about 95% of breast cancer patients, and measurement of body mass index of patients at the start and at the end of chemotherapy revealed more women occupied the obese strata after completing the chemotherapy. The study showed statistically significant differences in the weight changes among the age, weight at diagnosis, state of hormone receptor & marital status subgroups. The only significant predictors of body weight changes after completing chemotherapy were patient age and body mass index at time of diagnosis.
There is a significant weight gain in breast cancer patients in Basra Oncology Center after finishing chemotherapy.